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Issue 12, 2018
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Dual-channel fluorescence diagnosis of cancer cells/tissues assisted by OATP transporters and cysteine/glutathione

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Abstract

Although fluorescence imaging diagnosis of the differences between cancer cells and normal cells by targeting ligand-based fluorescent probes is useful for recommending personalized therapy to patients, using the differences to diagnose a wide range of cancers is often not possible due to the genetic or phenotypic heterogeneity of cancer cells. In this work a 2-(diphenylphosphino)phenol-functionalized pyronin POP was presented as a dual-channel fluorescence agent for diagnosing a wide range of cancer cell types. The agent could efficiently penetrate cancer cell, rather than normal cell, membranes by active transport of the organic-anion transporting polypeptide (OATP) transporters overexpressed in many types of cancer cell, and is then activated by intracellular cysteine (Cys) and glutathione (GSH) to produce green-emission aminopyronin NP and red-emission thiopyronin SP, thereby enabling its use in dual-channel fluorescence diagnosis of a wide range of cancer cells with excellent contrast. Crucially, POP also displays the ability of dual-channel fluorescence diagnosis of cancer tissues from tumour xenograft models of mice and harvested surgical specimens of patients, thus holding great potential for clinical applications.

Graphical abstract: Dual-channel fluorescence diagnosis of cancer cells/tissues assisted by OATP transporters and cysteine/glutathione

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Publication details

The article was received on 21 Dec 2017, accepted on 15 Feb 2018 and first published on 16 Feb 2018


Article type: Edge Article
DOI: 10.1039/C7SC05407F
Citation: Chem. Sci., 2018,9, 3209-3214
  • Open access: Creative Commons BY-NC license
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    Dual-channel fluorescence diagnosis of cancer cells/tissues assisted by OATP transporters and cysteine/glutathione

    H. Zhang, J. Liu, B. Hu, L. Wang, Z. Yang, X. Han, J. Wang, W. Bai and W. Guo, Chem. Sci., 2018, 9, 3209
    DOI: 10.1039/C7SC05407F

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      [Original citation] - Published by The Royal Society of Chemistry.

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