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Issue 12, 2018
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Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

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Abstract

Mechanochemistry is becoming more widespread as a technique for molecular synthesis with new mechanochemical reactions being discovered at increasing frequency. Whilst mechanochemical methods are solvent free and can therefore lead to improved sustainability metrics, it is more likely that the significant differences between reaction outcomes, reaction selectivities and reduced reaction times will make it a technique of interest to synthetic chemists. Herein, we provide an overview of mechanochemistry reaction examples, with ‘direct’ comparators to solvent based reactions, which collectively seemingly show that solid state grinding can lead to reduced reaction times, different reaction outcomes in product selectivity and in some instances different reaction products, including products not accessible in solution.

Graphical abstract: Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

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Publication details

The article was received on 18 Dec 2017, accepted on 26 Feb 2018 and first published on 07 Mar 2018


Article type: Perspective
DOI: 10.1039/C7SC05371A
Citation: Chem. Sci., 2018,9, 3080-3094
  • Open access: Creative Commons BY license
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    Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

    Joseph L. Howard, Q. Cao and D. L. Browne, Chem. Sci., 2018, 9, 3080
    DOI: 10.1039/C7SC05371A

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