Jump to main content
Jump to site search

Issue 9, 2018
Previous Article Next Article

Intra-mitochondrial biomineralization for inducing apoptosis of cancer cells

Author affiliations

Abstract

The use of biomineralization that regulates cellular functions has emerged as a potential therapeutic tool. However, the lack of selectivity still limits its therapeutic efficacy. Here, we report a subcellular-targeting biomineralization system featuring a triphenylphosphonium cation (TPP) (the mitochondria-targeting moiety) and trialkoxysilane (the biomineralization moiety via silicification). The TPP-containing trialkoxysilane exhibited approximately seven times greater cellular uptake into cancer cells (SCC7) than into normal cells (HEK293T) due to the more negative mitochondrial membrane potentials of the cancer cells. In turn, its accumulation inside mitochondria (pH 8) induces specific silicification, leading to the formation of silica particles in the mitochondrial matrix and further activation of apoptosis. In vivo assessment confirmed that the biomineralization system efficiently inhibits tumor growth in a mouse xenograft cancer model. Exploiting both the subcellular specificity and the targeting strategy provides new insight into the use of intracellular biomineralization for targeted cancer therapy.

Graphical abstract: Intra-mitochondrial biomineralization for inducing apoptosis of cancer cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Dec 2017, accepted on 24 Jan 2018 and first published on 25 Jan 2018


Article type: Edge Article
DOI: 10.1039/C7SC05189A
Citation: Chem. Sci., 2018,9, 2474-2479
  • Open access: Creative Commons BY license
  •   Request permissions

    Intra-mitochondrial biomineralization for inducing apoptosis of cancer cells

    S. Kim, L. Palanikumar, H. Choi, M. T. Jeena, C. Kim and J. Ryu, Chem. Sci., 2018, 9, 2474
    DOI: 10.1039/C7SC05189A

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements