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Tailoring the morphology of AIEgen fluorescent nanoparticles for optimal cellular uptake and imaging efficacy

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Abstract

The rational design of robust fluorescent organic materials for long-term cell tracing is still challenging, and aggregation-caused quenching of emission is a big limitation of this strategy. Organic dyes with aggregation-induced emission (AIE) can effectively address this problem. Herein, AIEgen-containing nanoparticles, with different morphologies and emission, were prepared by assembling amphiphilic copolymers with an AIEgen. We compared the physical and chemical properties of rod-like and spherical nanoparticles, particularly investigating the effects of the shape on internalization and the imaging effect. The formulated nanoparticles exhibit advantageous features, such as a large Stokes shift, robust stability in physiological conditions, strong fluorescent emission, and photobleaching resistance. Interestingly, the rod-like nanoparticles were internalized more efficiently than their spherical counterparts, and their strong green fluorescence can still be clearly observed even after 15 days in vitro and in vivo. This work demonstrates the great potential of regulating the morphology of nanoparticles to obtain an ideal biological function.

Graphical abstract: Tailoring the morphology of AIEgen fluorescent nanoparticles for optimal cellular uptake and imaging efficacy

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Publication details

The article was received on 02 Dec 2017, accepted on 15 Jan 2018 and first published on 17 Jan 2018


Article type: Edge Article
DOI: 10.1039/C7SC05130A
Citation: Chem. Sci., 2018, Advance Article
  • Open access: Creative Commons BY license
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    Tailoring the morphology of AIEgen fluorescent nanoparticles for optimal cellular uptake and imaging efficacy

    J. Zhang, B. Xu, W. Tian and Z. Xie, Chem. Sci., 2018, Advance Article , DOI: 10.1039/C7SC05130A

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