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Issue 15, 2018
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Rational design of a water-soluble NIR AIEgen, and its application in ultrafast wash-free cellular imaging and photodynamic cancer cell ablation

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Abstract

The synthesis of water-soluble near-infrared (NIR)-emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics and theranostic functions is highly desirable but remains challenging. In this work, we designed and readily prepared for the first time such a molecule with AIE features, good water-solubility and intense emission in the NIR region. This AIE luminogen (AIEgen) is able to specifically “light up” the cell membrane without the involvement of a washing procedure. Interestingly, the staining process can be performed by simply shaking the culture with cells at room temperature for only a few seconds after the addition of the AIEgen, indicating an ultrafast and easy-to-operate staining protocol. This is the first fluorescent “light-up” probe for cell-imaging that allows the combination of a short staining period (at the second-level) with a wash-free process. Additionally, the presented AIEgen has also been developed to serve as an excellent phototherapeutic agent for high efficiency generation of reactive oxygen species (ROS) upon visible light irradiation, which allows its effective application in the photodynamic ablation of cancer cells, demonstrating its dual role as an imaging and phototherapeutic agent.

Graphical abstract: Rational design of a water-soluble NIR AIEgen, and its application in ultrafast wash-free cellular imaging and photodynamic cancer cell ablation

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Publication details

The article was received on 19 Nov 2017, accepted on 12 Mar 2018 and first published on 13 Mar 2018


Article type: Edge Article
DOI: 10.1039/C7SC04963C
Citation: Chem. Sci., 2018,9, 3685-3693
  • Open access: Creative Commons BY license
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    Rational design of a water-soluble NIR AIEgen, and its application in ultrafast wash-free cellular imaging and photodynamic cancer cell ablation

    D. Wang, H. Su, R. T. K. Kwok, X. Hu, H. Zou, Q. Luo, Michelle M. S. Lee, W. Xu, J. W. Y. Lam and B. Z. Tang, Chem. Sci., 2018, 9, 3685
    DOI: 10.1039/C7SC04963C

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