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Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration

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Abstract

Reported here is a successful strategy for the design of ultrabright red luminogens with aggregation-induced emission (AIE) features, donor–acceptor structures, and intense charge transfer effects. These luminogens show no aggregation caused emission quenching in the solid state and have high quantum efficiency. They can be fabricated into AIE dots by a simple nanoprecipitation procedure. The AIE dots exhibit high brightness, a large Stokes shift, good biocompatibility, satisfactory photostability, and a high two-photon absorption cross section. The AIE dots can be utilized as highly efficient fluorescent probes for in vivo deep-tissue imaging by a two-photon technique, which outperforms the one-photon technique under the same experimental conditions, in terms of penetration depth and image contrast. This is the first report of using highly emissive AIE dots for the accurate measurement of capillary diameters in mouse ears. Such a strategy sheds light on the development of efficient solid state red/NIR emitters for biological applications.

Graphical abstract: Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration

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Publication details

The article was received on 08 Nov 2017, accepted on 31 Jan 2018 and first published on 31 Jan 2018


Article type: Edge Article
DOI: 10.1039/C7SC04820C
Citation: Chem. Sci., 2018, Advance Article
  • Open access: Creative Commons BY license
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    Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration

    W. Qin, P. Zhang, H. Li, J. W. Y. Lam, Y. Cai, R. T. K. Kwok, J. Qian, W. Zheng and B. Z. Tang, Chem. Sci., 2018, Advance Article , DOI: 10.1039/C7SC04820C

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