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Novel Dual-Function Near-Infrared II Fluorescence and PET Probe for Tumor Delineation and Image-Guided Surgery

Abstract

Accurate tumor identification is essential in cancer management. Incomplete excision of tumor tissue however negatively affects the prognosis of the patient. To accomplish radical excision of tumor tissue, radiotracers can be used that target tumor tissue and can be detected using a gamma probe during surgery and intraoperative fluorescence imaging could allow accurate real-time tumor delineation. Herein, a novel dual-modal imaging platform using base-catalyzed double addition of thiols into a propiolamide scaffold has been developed, allowing highly efficient and selective assembly of various thiol units in a protecting-group-free manner. The first small-molecule based αⅤβ3-targeted NIR-II/PET probe 68Ga-SCH2 was concisely generated via this strategy and subsequently evaluated in mice bearing U87MG xenograft. The excellent imaging properties such as good tumor uptake, high tumor contrast and specificity, tumor delineation and image-guided surgery were achieved in the small animal models. These attractive results of 68Ga-SCH2 allow it to be a promising αⅤβ3-targeted NIR-II/PET probe for clinical translation.

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Publication details

The article was received on 04 Nov 2017, accepted on 27 Dec 2017 and first published on 08 Jan 2018


Article type: Edge Article
DOI: 10.1039/C7SC04774F
Citation: Chem. Sci., 2018, Accepted Manuscript
  • Open access: Creative Commons BY license
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    Novel Dual-Function Near-Infrared II Fluorescence and PET Probe for Tumor Delineation and Image-Guided Surgery

    Y. Sun, X. Zeng, Y. Xiao, C. Liu, H. Zhu, H. Zhou, Z. Chen, F. Xu, J. Wang, M. Zhu, J. Wu, H. Zhang, Z. Deng, Z. Cheng and X. Hong, Chem. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7SC04774F

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