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Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones

Abstract

Misfolding of proteins is the basis of several proteinopathies. Chemical and pharmacological chaperones are small molecules capable of inducing the correct conformation of proteins, thus being of interest for human therapeutics. The most recent developments in medicinal chemistry and drug development of pharmacological chaperones is discussed, with focus in lysosomal storage diseaes.

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Publication details

The article was received on 31 Oct 2017, accepted on 10 Jan 2018 and first published on 10 Jan 2018


Article type: Perspective
DOI: 10.1039/C7SC04712F
Citation: Chem. Sci., 2018, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
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    Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones

    D. M. Pereira, P. Valentao and P. B. Andrade, Chem. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7SC04712F

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