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Issue 10, 2018
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Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: mapping heterogeneity and polymorphism

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Abstract

Heterogeneity and polymorphism are generic features of amyloid fibers with some important effects on the related disease development. We report here the characterization, by charge detection mass spectrometry, of amyloid fibers made of three polypeptides involved in neurodegenerative diseases: Aβ1–42 peptide, tau and α-synuclein. Beside the mass of individual fibers, this technique enables to characterize the heterogeneity and the polymorphism of the population. In the case of Aβ1–42 peptide and tau protein, several coexisting species could be distinguished and characterized. In the case of α-synuclein, we show how the polymorphism affects the mass and charge distributions.

Graphical abstract: Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: mapping heterogeneity and polymorphism

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Publication details

The article was received on 19 Oct 2017, accepted on 02 Feb 2018 and first published on 05 Feb 2018


Article type: Edge Article
DOI: 10.1039/C7SC04542E
Citation: Chem. Sci., 2018,9, 2791-2796
  • Open access: Creative Commons BY license
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    Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: mapping heterogeneity and polymorphism

    J. Pansieri, M. A. Halim, C. Vendrely, M. Dumoulin, F. Legrand, M. M. Sallanon, S. Chierici, S. Denti, X. Dagany, P. Dugourd, C. Marquette, R. Antoine and V. Forge, Chem. Sci., 2018, 9, 2791
    DOI: 10.1039/C7SC04542E

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