Jump to main content
Jump to site search


A Luminescent Aluminium Salen Complex Allows for Monitoring Dynamic Vesicle Trafficking from Golgi Apparatus to Lysosomes in Living Cells

Abstract

Golgi apparatus is well-known as the centre of vesicle trafficking whose malfunction might cause the breakdown of overall cellular architecture and ultimately cell death. Development of fluorescent probes not only to precisely stain Golgi apparatus but also to monitor dynamic vesicle trafficking is of great significance. While fluorescent proteins and fluorescent lipid analogs have been reported, they are limited by either overexpression and toxicity or lack of high selectivity. To overcome these limitations, we herein report a novel approach based on the metal-induced coordination between the phosphate anions of phospholipids and metal centre of luminescent AlSalen complex Golgi-Al, which can in situ track membrane vesicle from Golgi apparatus to lysosomes in living cells. This work opens a new avenue to designing luminescent metal probes based on Lewis acidity of metal ions and allows the use of metal ions with different charge state, polarity, and reactivity within a similar structural fold to expand coordination chemistry for biological studies.

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Oct 2017, accepted on 05 Jan 2018 and first published on 08 Jan 2018


Article type: Edge Article
DOI: 10.1039/C7SC04498D
Citation: Chem. Sci., 2018, Accepted Manuscript
  • Open access: Creative Commons BY license
  •   Request permissions

    A Luminescent Aluminium Salen Complex Allows for Monitoring Dynamic Vesicle Trafficking from Golgi Apparatus to Lysosomes in Living Cells

    J. Zhang, J. Tang and H. Yin, Chem. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7SC04498D

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements