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Issue 8, 2018
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Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

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Abstract

The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.

Graphical abstract: Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

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Publication details

The article was received on 02 Oct 2017, accepted on 19 Jan 2018 and first published on 19 Jan 2018


Article type: Edge Article
DOI: 10.1039/C7SC04287F
Citation: Chem. Sci., 2018,9, 2290-2294
  • Open access: Creative Commons BY license
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    Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

    R. Dandela, D. Mantin, B. F. Cravatt, J. Rayo and Michael M. Meijler, Chem. Sci., 2018, 9, 2290
    DOI: 10.1039/C7SC04287F

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