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A Catalytic Highly Enantioselective Allene Approach to Oxazolines

Abstract

Oxazolines are a very important class of heterocyclic compounds. However, catalytic enantioselective syntheses are very limited. Here, a highly enantioselective palladium-catalyzed coupling-cyclization of readily available N-(buta-2,3-dienyl) amides with aryl or 1-alkenyl iodides has been developed for the asymmetric construction of oxazoline derivatives. Many synthetically useful functional groups are tolerated in this reaction. The absolute configuration of the chiral center in the products has been established by X-ray diffraction study. A model for prediction of the absolute configuration of the chiral center in the products from this cyclic enantioselective nucleophilic allylation has been proposed. The synthetic potentials based on the unique structure of the products formed have also been demonstrated.

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Publication details

The article was received on 17 Sep 2017, accepted on 02 Jan 2018 and first published on 05 Jan 2018


Article type: Edge Article
DOI: 10.1039/C7SC04079B
Citation: Chem. Sci., 2018, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
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    A Catalytic Highly Enantioselective Allene Approach to Oxazolines

    H. Luo, Z. Yang, W. Lin, Y. Zheng and S. Ma, Chem. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7SC04079B

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