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Injectable hyperbranched poly(β-amino ester) hydrogels with on-demand degradation profile to match wound healing process

Abstract

Adjusting biomaterial degradation profile to match tissue regeneration is a challenging issue. Herein, the biodegradable hyperbranched poly(β-amino ester)s (HP-PBAE)s were designed and synthesized via “A2 + B4” Michael addition polymerization, which displayed fast gelation with thiolated hyaluronic acid (HA-SH) via “click” thiol-ene reaction. HP-PBAE/HA-SH hydrogels showed tunable degradation profiles both in vitro and in vivo by using diamines with different alkyl chain lengths and poly(ethylene glycol) diacrylates with varied PEG spacers. The hydrogels with optimized degradation profiles encapsulating ADSCs were used as injectable hydrogels to treat two different types of humanized excisional wounds - acute wounds with faster healing rate and diabetic wounds with slower healing and neo-tissue formation. The fast-degrading hydrogel had the accelerated wound closure in acute wounds, while the slow-degrading hydrogel showed better wound healing for diabetic wounds. The results demonstrate that the new HP-PBAE-based hydrogel in combination with ADSCs can be used as a well-controlled biodegradable skin substitute, which demonstrates a promising approach in the treatment of various types of skin wounds.

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Publication details

The article was received on 06 Sep 2017, accepted on 04 Jan 2018 and first published on 08 Jan 2018


Article type: Edge Article
DOI: 10.1039/C7SC03913A
Citation: Chem. Sci., 2018, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
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    Injectable hyperbranched poly(β-amino ester) hydrogels with on-demand degradation profile to match wound healing process

    Q. Xu, L. Guo, S. A, Y. Gao, D. Zhou, U. Greiser, J. Creagh-Flynn, H. Zhang, Y. Dong, L. Cutlar, F. Wang, W. Liu, W. Wang and W. Wang, Chem. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7SC03913A

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