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Direct sulfonylation of anilines mediated by visible light

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Abstract

Sulfones feature prominently in biologically active molecules and are key functional groups for organic synthesis. We report a mild, photoredox-catalyzed reaction for sulfonylation of aniline derivatives with sulfinate salts, and demonstrate the utility of the method by the late-stage functionalization of drugs. Key features of the method are the straightforward generation of sulfonyl radicals from bench-stable sulfinate salts and the use of simple aniline derivatives as convenient readily available coupling partners.

Graphical abstract: Direct sulfonylation of anilines mediated by visible light

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Publication details

The article was received on 05 Sep 2017, accepted on 07 Nov 2017 and first published on 16 Nov 2017


Article type: Edge Article
DOI: 10.1039/C7SC03891G
Citation: Chem. Sci., 2018, Advance Article
  • Open access: Creative Commons BY license
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    Direct sulfonylation of anilines mediated by visible light

    T. C. Johnson, Bryony L. Elbert, A. J. M. Farley, T. W. Gorman, C. Genicot, B. Lallemand, P. Pasau, J. Flasz, J. L. Castro, M. MacCoss, D. J. Dixon, R. S. Paton, C. J. Schofield, M. D. Smith and M. C. Willis, Chem. Sci., 2018, Advance Article , DOI: 10.1039/C7SC03891G

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