Jump to main content
Jump to site search


Accelerated multi-reagent copper catalysed coupling reactions in micro droplets and thin films

Author affiliations

Abstract

Electrospray (ES) and paper spray (PS) mass spectrometry were used to create confined liquid volumes in which accelerated air and water sensitive, heterogeneous, copper catalysed C–O and C–N coupling reactions occur. Significant reaction acceleration was observed compared to the bulk reaction which required elevated temperatures and time for completion. Macroscopic amounts of product (mg scale) were prepared using offline ES within minutes. The trends in reactivity observed for several reagents matched those of the bulk reactions making droplet accelerated reactions good mimics of the bulk chemistry.

Graphical abstract: Accelerated multi-reagent copper catalysed coupling reactions in micro droplets and thin films

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Jan 2018, accepted on 08 Feb 2018 and first published on 08 Feb 2018


Article type: Paper
DOI: 10.1039/C8RE00002F
Citation: React. Chem. Eng., 2018, Advance Article
  •   Request permissions

    Accelerated multi-reagent copper catalysed coupling reactions in micro droplets and thin films

    K. Iyer, J. Yi, A. Bogdan, N. Talaty, S. W. Djuric and R. G. Cooks, React. Chem. Eng., 2018, Advance Article , DOI: 10.1039/C8RE00002F

Search articles by author

Spotlight

Advertisements