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Mechanistic insight into oxidized N,N-dimethylacetamide as a source of formaldehyde related derivatives

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Abstract

A hemiaminal derivative identified during preparation of the penultimate of ceftolozane 1, mandated a thorough investigation of the source of the impurity. N,N-Dimethylacetamide (DMAc) subjected to oxidation was found to be the culprit generating oxidized products that serve as sources of the hemiaminal derivative. Identification of DMAc as a source of formaldehyde derivatives and the mechanism of DMAc oxidation are elaborated.

Graphical abstract: Mechanistic insight into oxidized N,N-dimethylacetamide as a source of formaldehyde related derivatives

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Publication details

The article was received on 01 Dec 2017, accepted on 06 Feb 2018 and first published on 06 Feb 2018


Article type: Communication
DOI: 10.1039/C7RE00199A
Citation: React. Chem. Eng., 2018, Advance Article
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    Mechanistic insight into oxidized N,N-dimethylacetamide as a source of formaldehyde related derivatives

    D. Zewge, X. Bu, H. Sheng, Y. Liu, Z. Liu, B. Harman, M. Reibarkh and X. Gong, React. Chem. Eng., 2018, Advance Article , DOI: 10.1039/C7RE00199A

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