Jump to main content
Jump to site search


Batch–flow hybrid synthesis of the antipsychotic clozapine

Author affiliations

Abstract

The development of batch–flow hybrid processes is becoming an attractive prospect through which chemists can make use of the best aspects of both technologies. We have reported the implementation of an on-the-fly purification by trituration which can also be utilised to perform solvent swaps. We have demonstrated this concept through the synthesis of the antipsychotic clozapine. In addition, we report a novel means of performing a reduction of an aryl nitro group under flow conditions and an overall improved process route for the total synthesis of clozapine.

Graphical abstract: Batch–flow hybrid synthesis of the antipsychotic clozapine

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Sep 2017, accepted on 22 Nov 2017 and first published on 22 Nov 2017


Article type: Paper
DOI: 10.1039/C7RE00146K
Citation: React. Chem. Eng., 2018, Advance Article
  •   Request permissions

    Batch–flow hybrid synthesis of the antipsychotic clozapine

    N. C. Neyt and D. L. Riley, React. Chem. Eng., 2018, Advance Article , DOI: 10.1039/C7RE00146K

Search articles by author

Spotlight

Advertisements