Issue 41, 2018
From the journal:

RSC Advances

A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder†

Chun-Qiong Zhou, ORCID logo *a   Zi-Qi Li,a   Ting-Cong Liao,a   Tian-Zhu Ma,a   Shuo-Bin Chen ORCID logo b  and  Yuan-Yuan Lianga  

* Corresponding authors

a Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
E-mail: zcqlg@smu.edu.cn
Fax: +86 20 61648549

b School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 51006, China

Abstract

A novel phenanthroimidazole ethylenediamine Pt(II) complex with coumarin derivative (1) was synthesized and showed higher affinity, selectivity and thermal stabilization for mixed-type dimeric G-quadruplexes (G2T1) over monomeric G-quadruplexes (G1) and duplex DNA. Complex 1 could bind to G-quadruplexes via end-stacking and external-binding modes.

Graphical abstract: A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder

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Article information

DOI
https://doi.org/10.1039/C8RA03606C
Article type
Paper
Submitted
26 Apr 2018
Accepted
12 Jun 2018
First published
26 Jun 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 23257-23261

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A novel square-planar Pt(II) complex as a monomeric and dimeric G-quadruplex DNA binder

C. Zhou, Z. Li, T. Liao, T. Ma, S. Chen and Y. Liang, RSC Adv., 2018, 8, 23257 DOI: 10.1039/C8RA03606C

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