Issue 27, 2018, Issue in Progress

Bioactive terpenoids from Santalum album derived endophytic fungus Fusarium sp. YD-2

Abstract

Two new spiromeroterpenoids, namely fusariumin A (1) and B (2), along with four known terpenoids, asperterpenoid A (3), agathic acid (4), guignardone N (5), and trametenolic acid (6), were obtained from the endophytic fungus Fusarium sp. YD-2, derived from the twigs of Santalum album. Their structures were elucidated by a combination of spectroscopic analyses. The absolute configuration of 1 was determined by single-crystal X-ray diffraction using Cu Kα radiation, and that of 2 was elucidated on the basis of experimental and calculated electronic circular dichroism spectra. Compound 2 exhibited moderate anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide activated RAW264.7 cells with an IC50 value of 50 μM, and compound 3 showed strong anti-inflammatory activity with an IC50 value of 1.6 μM. In the antibacterial assay, compound 1 displayed significant activities against Staphylococcus aureus and Pseudomonas aeruginosa with an MIC value of 6.3 μg mL−1, and compound 3 showed moderate activities against Salmonella enteritidis and Micrococcus luteus with MIC values of 6.3 and 25.2 μg mL−1, respectively.

Graphical abstract: Bioactive terpenoids from Santalum album derived endophytic fungus Fusarium sp. YD-2

Supplementary files

Article information

Article type
Paper
Submitted
20 Mar 2018
Accepted
12 Apr 2018
First published
19 Apr 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 14823-14828

Bioactive terpenoids from Santalum album derived endophytic fungus Fusarium sp. YD-2

C. Yan, W. Liu, J. Li, Y. Deng, S. Chen and H. Liu, RSC Adv., 2018, 8, 14823 DOI: 10.1039/C8RA02430H

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