Issue 25, 2018

Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones

Abstract

A palladium catalyzed synthesis of N–H phenanthridinones was developed via C–H arylation. The protocol gives phenanthridinones regioselectively by one-pot reaction without deprotection. It exhibits broad substrate scope and affords targets in up to 95% yields. Importantly, it could be applied for the less reactive o-chlorobenzamides.

Graphical abstract: Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones

Supplementary files

Article information

Article type
Paper
Submitted
09 Mar 2018
Accepted
05 Apr 2018
First published
13 Apr 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 13879-13890

Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones

Q. Hu, T. Gao, Y. Shi, Q. Lei and L. Yu, RSC Adv., 2018, 8, 13879 DOI: 10.1039/C8RA02099J

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