Issue 24, 2018, Issue in Progress

Two azobenzene derivatives CAB/ACB as reusable sunscreen: UV absorptive capacity and biosafety evaluation

Abstract

Exposure to UV radiation may cause harmful effects to the skin such as damage, aging and cancer, which can be prevented by using sunscreens. Here, two azobenzene derivatives, 4-cholesterocarbonyl-4′-(N,N,N-triethylaminebutyloxyl bromide) azobenzene (CAB) and 4-cholesterocarbonyl-4′-(N,N-diethylaminebutyloxyl) azobenzene (ACB) were studied as reusable sunscreen candidates. Biocompatibility studies including apoptosis, cytotoxicity and in vivo phototoxicity revealed that the two compounds were rather safe, except ACB, which showed a weak phototoxicity in vitro. Both CAB and ACB have good UV absorption capacity not only in their solution state (dimethylsulfoxide, DMSO) but also in the cosmetic cream state. A commercial sunscreen, avobenzone was decomposed upon UV irradiation and lost its UV protection ability, while that of CAB and ACB could be quickly recovered upon visible light irradiation, implying that they can serve as a new type of reusable sunscreen.

Graphical abstract: Two azobenzene derivatives CAB/ACB as reusable sunscreen: UV absorptive capacity and biosafety evaluation

Supplementary files

Article information

Article type
Paper
Submitted
16 Sep 2017
Accepted
19 Mar 2018
First published
10 Apr 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 13274-13283

Two azobenzene derivatives CAB/ACB as reusable sunscreen: UV absorptive capacity and biosafety evaluation

J. Liu, S. Wada and J. Wang, RSC Adv., 2018, 8, 13274 DOI: 10.1039/C7RA10290A

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