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Organocatalytic Asymmetric [3+2] Annulation of 1, 4-Dithiane-2, 5-diol with Azlactones: Access to Chiral Dihydrothiophen-2(3H)-one Derivatives

Abstract

Herein, the first organocatalytic-mediated enantioselective [3+2] annulations of 1, 4-dithiane-2, 5-diol with various azlactones utilizing C4, C5 reactivity under using squaramide as the catalyst in ring-opening manner has been reported. This protocol provides a convenient access to enantioenriched substituted dihydrothiophen-2(3H)-one derivatives. Excellent isolated yields and moderate to good enantioselectivities.

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Publication details

The article was received on 20 Mar 2018, accepted on 07 May 2018 and first published on 09 May 2018


Article type: Research Article
DOI: 10.1039/C8QO00305J
Citation: Org. Chem. Front., 2018, Accepted Manuscript
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    Organocatalytic Asymmetric [3+2] Annulation of 1, 4-Dithiane-2, 5-diol with Azlactones: Access to Chiral Dihydrothiophen-2(3H)-one Derivatives

    J. Yu, L. Yu, X. Zhao, L. Gan, W. Zhu, Z. Wang, R. Wang and X. Jiang, Org. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QO00305J

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