Palladium-catalyzed direct approach to α-CF3 aryl ketones from arylboronic acids

Abstract

A concise and practical method for the synthesis of α-CF₃ aryl ketones using stable and commercially available arylboronic acids and ICH₂CF₃ was reported. The α-CF₃ aryl ketones could be easily obtained using a CO balloon (1 atm) in the presence of a palladium catalyst. This protocol provided a direct approach for the synthesis of α-CF₃ aryl ketones from carbonylative cross-coupling reactions from easily accessible starting materials and the one-step reaction was conducted under a very practical CO pressure.