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Issue 11, 2018
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Decarboxylative formylation of aryl halides with glyoxylic acid by merging organophotoredox with palladium catalysis

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Abstract

Decarboxylative formylation of aryl and heteroaryl halides with glyoxylic acid is enabled by synergistic catalysis using an organic dye, 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile (4CzIPN), and a phosphine ligated palladium catalyst under mild irradiation conditions. A wide range of aryl halides and heteroaryl halides are amenable to deliver functionalized aryl and heteroaryl aldehydes. The reaction represents a new application of organophotoredox/palladium synergistic catalysis for catalytic decarboxylative cross-couplings.

Graphical abstract: Decarboxylative formylation of aryl halides with glyoxylic acid by merging organophotoredox with palladium catalysis

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Publication details

The article was received on 08 Mar 2018, accepted on 31 Mar 2018 and first published on 02 Apr 2018


Article type: Research Article
DOI: 10.1039/C8QO00253C
Citation: Org. Chem. Front., 2018,5, 1782-1786
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    Decarboxylative formylation of aryl halides with glyoxylic acid by merging organophotoredox with palladium catalysis

    B. Zhao, R. Shang, W. Cheng and Y. Fu, Org. Chem. Front., 2018, 5, 1782
    DOI: 10.1039/C8QO00253C

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