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Synthesis of fused benzimidazoles via successive nucleophilic additions of benzimidazole derivatives to arynes under transition metal-free conditions

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Abstract

An expedient and efficient strategy was developed for the synthesis of benzimidazole derivatives from aryne precursors with CsF and K2CO3 under transition metal-free conditions. The reaction exhibited good functional group tolerance, as substrates containing alkyls, ethers, nitryls, halogens etc., could all undergo the reaction smoothly, and afforded the desired products in good to excellent yields.

Graphical abstract: Synthesis of fused benzimidazoles via successive nucleophilic additions of benzimidazole derivatives to arynes under transition metal-free conditions

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Publication details

The article was received on 08 Mar 2018, accepted on 15 Mar 2018 and first published on 26 Mar 2018


Article type: Research Article
DOI: 10.1039/C8QO00251G
Citation: Org. Chem. Front., 2018, Advance Article
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    Synthesis of fused benzimidazoles via successive nucleophilic additions of benzimidazole derivatives to arynes under transition metal-free conditions

    B. Li, S. Mai and Q. Song, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00251G

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