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Issue 10, 2018
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Total synthesis of the isoquinoline alkaloid decumbenine B via Ru(III)-catalyzed C–H activation

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Abstract

A novel and efficient method for the total synthesis of the natural product decumbenine B was described. The shortcomings in the existing synthetic routes of this isoquinoline alkaloid were minimized through the application of Ru(III)-catalyzed direct ortho-hydroxymethylation of intermediate 9. With this method, decumbenine B could be easily synthesized from commercially available materials by only five steps with an overall yield of 26.1%.

Graphical abstract: Total synthesis of the isoquinoline alkaloid decumbenine B via Ru(iii)-catalyzed C–H activation

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Publication details

The article was received on 22 Feb 2018, accepted on 21 Mar 2018 and first published on 23 Mar 2018


Article type: Research Article
DOI: 10.1039/C8QO00193F
Citation: Org. Chem. Front., 2018,5, 1604-1607
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    Total synthesis of the isoquinoline alkaloid decumbenine B via Ru(III)-catalyzed C–H activation

    Y. Zhang, Z. Yang, L. Guo, W. Li, X. Cheng, X. Wang, Q. Wang, L. Hai and Y. Wu, Org. Chem. Front., 2018, 5, 1604
    DOI: 10.1039/C8QO00193F

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