Jump to main content
Jump to site search


An efficient approach to 4-chloro quinolines via TMSCl-mediated cascade cyclization of ortho-propynol phenyl azides

Author affiliations

Abstract

A novel and efficient strategy for the synthesis of 4-chloro quinolines via the TMSCl-mediated cascade cyclization of easily prepared ortho-propynol phenyl azides is developed. This reaction proceeds smoothly in moderate to excellent yields with a wide range of substrate compatibility. TMSCl acted not only as a promoter, but also as a chloro source in this transformation. Moreover, the obtained 4-chloro quinolines could be further derivated in an array of palladium-catalyzed coupling and nucleophilic substitution reactions to construct potential biologically active and pharmaceutical molecules.

Graphical abstract: An efficient approach to 4-chloro quinolines via TMSCl-mediated cascade cyclization of ortho-propynol phenyl azides

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Feb 2018, accepted on 21 Mar 2018 and first published on 21 Mar 2018


Article type: Research Article
DOI: 10.1039/C8QO00162F
Citation: Org. Chem. Front., 2018, Advance Article
  •   Request permissions

    An efficient approach to 4-chloro quinolines via TMSCl-mediated cascade cyclization of ortho-propynol phenyl azides

    X. Song, R. Li, H. Ding, X. Chen, T. Yang, J. Bai, Q. Xiao and Y. Liang, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00162F

Search articles by author

Spotlight

Advertisements