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Total synthesis of C19-diterpenoid alkaloid: construction of a functionalized ABCDE-ring system

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Abstract

A synthetic approach for the ABCDE ring system of methyllycaconitine starting from a BCD tricycle precursor 14 was described. The synthesis features a useful strategy for the full functionalization of ring B, a 1,7-enyne reductive radical cyclization for the construction of ring A, and a straightforward double condensation for installation of the piperidine ring E.

Graphical abstract: Total synthesis of C19-diterpenoid alkaloid: construction of a functionalized ABCDE-ring system

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Publication details

The article was received on 06 Feb 2018, accepted on 14 Mar 2018 and first published on 15 Mar 2018


Article type: Research Article
DOI: 10.1039/C8QO00143J
Citation: Org. Chem. Front., 2018, Advance Article
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    Total synthesis of C19-diterpenoid alkaloid: construction of a functionalized ABCDE-ring system

    M. Liu, C. Cheng, W. Xiong, H. Cheng, J. Wang and L. Xu, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00143J

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