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Issue 11, 2018
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Iridium-catalysed conjugated alkynylation of α,β-unsaturated amide through alkene isomerization

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Abstract

We have developed an iridium-catalysed conjugated alkynylation of α,β-unsaturated amide. The catalyst system is applicable to a variety of α,β-unsaturated amides. Experimental and computational data suggest that the alkynylation does not occur directly at the α,β-unsaturated amide. Instead, it occurs through a β-selective hydroalkynylation of β,γ-unsaturated amide.

Graphical abstract: Iridium-catalysed conjugated alkynylation of α,β-unsaturated amide through alkene isomerization

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Publication details

The article was received on 05 Feb 2018, accepted on 20 Apr 2018 and first published on 24 Apr 2018


Article type: Research Article
DOI: 10.1039/C8QO00136G
Citation: Org. Chem. Front., 2018,5, 1815-1819
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    Iridium-catalysed conjugated alkynylation of α,β-unsaturated amide through alkene isomerization

    Y. Chen, Z. Wang, Q. Li, L. Xu and B. Li, Org. Chem. Front., 2018, 5, 1815
    DOI: 10.1039/C8QO00136G

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