Issue 11, 2018

Iridium-catalysed conjugated alkynylation of α,β-unsaturated amide through alkene isomerization

Abstract

We have developed an iridium-catalysed conjugated alkynylation of α,β-unsaturated amide. The catalyst system is applicable to a variety of α,β-unsaturated amides. Experimental and computational data suggest that the alkynylation does not occur directly at the α,β-unsaturated amide. Instead, it occurs through a β-selective hydroalkynylation of β,γ-unsaturated amide.

Graphical abstract: Iridium-catalysed conjugated alkynylation of α,β-unsaturated amide through alkene isomerization

Supplementary files

Article information

Article type
Research Article
Submitted
05 Feb 2018
Accepted
20 Apr 2018
First published
24 Apr 2018

Org. Chem. Front., 2018,5, 1815-1819

Iridium-catalysed conjugated alkynylation of α,β-unsaturated amide through alkene isomerization

Y. Chen, Z. Wang, Q. Li, L. Xu and B. Li, Org. Chem. Front., 2018, 5, 1815 DOI: 10.1039/C8QO00136G

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