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Issue 9, 2018
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Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives

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Abstract

A facile synthetic method to access 4-amino-isoquinolin-1(2H)-one and oxazole derivatives was disclosed in this paper. The reaction of N-(pivaloyloxy)-amides with ynamides produced 4-amino-isoquinolin-1(2H)-ones in good yields in the presence of Cp*Rh(III) catalyst through a C–H bond functionalization. Using Sc(OTf)3 as the catalyst, oxazole derivatives were obtained in good yields from the same reaction. This protocol features good functional group tolerance and excellent regioselectivity.

Graphical abstract: Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives

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Publication details

The article was received on 03 Feb 2018, accepted on 05 Mar 2018 and first published on 08 Mar 2018


Article type: Research Article
DOI: 10.1039/C8QO00125A
Citation: Org. Chem. Front., 2018,5, 1466-1470
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    Catalyst-controlled synthesis of 4-amino-isoquinolin-1(2H)-one and oxazole derivatives

    B. Niu, R. Liu, Y. Wei and M. Shi, Org. Chem. Front., 2018, 5, 1466
    DOI: 10.1039/C8QO00125A

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