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Asperones A–E, five dimeric polyketides with new carbon skeletons from the fungus Aspergillus sp. AWG 1–15

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Abstract

Asperones A–E (1–5), five dimeric polyketides with two distinct skeletons generated by the crucial [3 + 2] and [3 + 3] cycloadditions, were isolated from fungal metabolites of an Aspergillus sp. Their structures were established by spectroscopic data, chemical derivatization, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compounds 2–4 showed significant nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells, and exhibited IC50 values of 16.0, 13.2, and 6.0 μM, respectively.

Graphical abstract: Asperones A–E, five dimeric polyketides with new carbon skeletons from the fungus Aspergillus sp. AWG 1–15

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Publication details

The article was received on 21 Jan 2018, accepted on 14 Mar 2018 and first published on 15 Mar 2018


Article type: Research Article
DOI: 10.1039/C8QO00070K
Citation: Org. Chem. Front., 2018, Advance Article
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    Asperones A–E, five dimeric polyketides with new carbon skeletons from the fungus Aspergillus sp. AWG 1–15

    G. Yin, Y. Wu, C. Han, X. Wang, H. Gao, Y. Yin, L. Kong and M. Yang, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00070K

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