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Issue 11, 2018
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I2-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo[1,2-a]pyridines and indolizines

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Abstract

An efficient and green protocol for the synthesis of acylated imidazo[1,2-a]pyridines and indolizines via intramolecular dehydrogenative aminooxygenation of alkynes has been developed. The reaction proceeds smoothly utilizing I2 as a catalyst and TBHP as an oxidant with a broad substrate scope. Mechanism studies reveal that the reaction maybe experiences a hydration followed by an oxidative cycloamination process.

Graphical abstract: I2-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo[1,2-a]pyridines and indolizines

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Publication details

The article was received on 19 Jan 2018, accepted on 26 Mar 2018 and first published on 27 Mar 2018


Article type: Research Article
DOI: 10.1039/C8QO00063H
Citation: Org. Chem. Front., 2018,5, 1772-1776
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    I2-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo[1,2-a]pyridines and indolizines

    Y. He, W. Yin, J. Wang, J. Huang, X. Pang, C. Gan, F. Yang and C. Huang, Org. Chem. Front., 2018, 5, 1772
    DOI: 10.1039/C8QO00063H

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