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Issue 10, 2018
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A facile hydroxylation of arylboronic acids mediated by sodium ascorbate

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Abstract

A simple, direct and facile hydroxylation of arylboronic acids has been described. The reaction is carried out under air, in an open flask, using 2 equivalents of sodium ascorbate. A variety of arylboronic acids can be transformed into the corresponding phenols in excellent to moderate isolated yields. The reaction tolerated the presence of functional groups, and molecules that are readily oxidized by H2O2 can be present in the reaction mixture. This green methodology avoids the use of photoredox conditions, transition metals, or other strong oxidants.

Graphical abstract: A facile hydroxylation of arylboronic acids mediated by sodium ascorbate

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Publication details

The article was received on 19 Jan 2018, accepted on 21 Feb 2018 and first published on 21 Feb 2018


Article type: Research Article
DOI: 10.1039/C8QO00061A
Citation: Org. Chem. Front., 2018,5, 1573-1578
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    A facile hydroxylation of arylboronic acids mediated by sodium ascorbate

    A. Gualandi, A. Savoini, R. Saporetti, P. Franchi, M. Lucarini and P. G. Cozzi, Org. Chem. Front., 2018, 5, 1573
    DOI: 10.1039/C8QO00061A

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