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Issue 8, 2018
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Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

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Abstract

Visible light, in combination with the molecular iodine catalyst-mediated α-hydroxylation of α-methylene ketones, has been developed. The reaction proceeds smoothly in methanol at room temperature under aerobic conditions and shows exclusive selectivity toward methylene ketones. Mechanistic studies have revealed that the reaction proceeds by a radical pathway. Renewable energy, metal-free catalyst and abundant oxygen source alongside a wide scope and novel selectivity are features that make this strategy practical and eco-friendly.

Graphical abstract: Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

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Publication details

The article was received on 18 Jan 2018, accepted on 22 Feb 2018 and first published on 23 Feb 2018


Article type: Research Article
DOI: 10.1039/C8QO00056E
Citation: Org. Chem. Front., 2018,5, 1325-1329
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    Visible-light-mediated iodine-catalyzed α-hydroxylation of α-methylene ketones under aerobic conditions

    J. Yang, D. Xie, H. Zhou, S. Chen, C. Huo and Z. Li, Org. Chem. Front., 2018, 5, 1325
    DOI: 10.1039/C8QO00056E

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