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One-pot regioselective synthesis of 2,4-disubstituted quinolines via copper(II)-catalyzed cascade annulation

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Abstract

A copper(II)-catalyzed cascade annulation of simple anilines with two molecules of alkyne esters for the one-pot synthesis of 2,4-disubstituted quinolines, with exclusive regioselectivity and excellent substrate/functional group tolerance, is herein described. Moreover, the second molecule of alkyne ester in the reaction was extended to encompass (hetero)aryl- or cycloalkyl-ketone substrates, which further demonstrates the viability of the present Cu(II)-catalyzed system.

Graphical abstract: One-pot regioselective synthesis of 2,4-disubstituted quinolines via copper(ii)-catalyzed cascade annulation

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Publication details

The article was received on 18 Jan 2018, accepted on 26 Mar 2018 and first published on 27 Mar 2018


Article type: Research Article
DOI: 10.1039/C8QO00052B
Citation: Org. Chem. Front., 2018, Advance Article
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    One-pot regioselective synthesis of 2,4-disubstituted quinolines via copper(II)-catalyzed cascade annulation

    W. Wu, Y. Guo, X. Xu, Z. Zhou, X. Zhang, B. Wu and W. Yi, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00052B

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