Jump to main content
Jump to site search

Issue 9, 2018
Previous Article Next Article

Diastereo- and enantioselective construction of chiral cyclopenta[b]indole framework via a catalytic asymmetric tandem cyclization of 2-indolymethanols with 2-naphthols

Author affiliations

Abstract

A catalytic asymmetric tandem cyclization of 2-indolymethanols with 2-naphthols has been established in the presence of chiral phosphoric acids, which constructed chiral cyclopenta[b]indole frameworks in generally good yields (up to 90%), high diastereoselectivities (up to >95 : 5 dr) and excellent enantioselectivities (up to 96% ee). This reaction not only provides an easy access to chiral cyclopenta[b]indole scaffolds, but also advances the chemistry of indolylmethanols, especially catalytic asymmetric transformations of indolylmethanols.

Graphical abstract: Diastereo- and enantioselective construction of chiral cyclopenta[b]indole framework via a catalytic asymmetric tandem cyclization of 2-indolymethanols with 2-naphthols

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Jan 2018, accepted on 19 Feb 2018 and first published on 19 Feb 2018


Article type: Research Article
DOI: 10.1039/C8QO00014J
Citation: Org. Chem. Front., 2018,5, 1436-1445
  •   Request permissions

    Diastereo- and enantioselective construction of chiral cyclopenta[b]indole framework via a catalytic asymmetric tandem cyclization of 2-indolymethanols with 2-naphthols

    J. Wu, J. Wang, P. Wu, J. Wang, G. Mei and F. Shi, Org. Chem. Front., 2018, 5, 1436
    DOI: 10.1039/C8QO00014J

Search articles by author

Spotlight

Advertisements