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Biomimetic total synthesis of homodimericin A

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Abstract

Homodimericin A is a fascinating fungal metabolite and a highly oxygenated cage-like polyketide. A practical total synthesis of homodimericin A has been achieved in 7 steps. The synthesis features a basic aqueous buffer promoted dimerization of quinone monomers, a thermal intramolecular Diels–Alder reaction and a carbonyl–ene cyclization cascade.

Graphical abstract: Biomimetic total synthesis of homodimericin A

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Publication details

The article was received on 28 Dec 2017, accepted on 23 Jan 2018 and first published on 24 Jan 2018


Article type: Research Article
DOI: 10.1039/C7QO01161J
Citation: Org. Chem. Front., 2018, Advance Article
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    Biomimetic total synthesis of homodimericin A

    X. Long, Y. Huang, Y. Long and J. Deng, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO01161J

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