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Issue 7, 2018
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Cooperation of copper and dioxygen for the site-selective construction of benzo[1,5]diazocin-6(5H)-ones from indoles and enaminone analogues

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Abstract

A new route for the preparation of benzo[1,5]diazocines from indoles and enaminone analogues is described. This protocol features easily available substrates, mild reaction conditions, high atom economy, environmentally friendly oxidants and site-selectivity. In addition, a plausible mechanism involving a cascade of copper-catalyzed oxidation/intermolecular cyclization/oxygen-participated intramolecular ring-opening is suggested.

Graphical abstract: Cooperation of copper and dioxygen for the site-selective construction of benzo[1,5]diazocin-6(5H)-ones from indoles and enaminone analogues

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Publication details

The article was received on 25 Dec 2017, accepted on 29 Jan 2018 and first published on 30 Jan 2018


Article type: Research Article
DOI: 10.1039/C7QO01154G
Citation: Org. Chem. Front., 2018,5, 1194-1201
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    Cooperation of copper and dioxygen for the site-selective construction of benzo[1,5]diazocin-6(5H)-ones from indoles and enaminone analogues

    W. Cao, B. Liu, X. Xu and S. Ji, Org. Chem. Front., 2018, 5, 1194
    DOI: 10.1039/C7QO01154G

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