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Issue 8, 2018
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Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis

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Abstract

Salviyunnanone A (1), a cytotoxic diterpenoid possessing an unprecedented 7/5/6/3 ring system derived from a normal abietane skeleton, was characterized from Salvia yunnanensis. Its structure was established by extensive MS and NMR spectroscopic analyses and its absolute configuration was defined by the comparison of experimental and calculated ECDs. The synthetic study of 1 was carried out and its 6-epi-isomer (12) was achieved in 9 steps involving the conjugated addition of an aryl boronic acid as a key step.

Graphical abstract: Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis

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Publication details

The article was received on 21 Dec 2017, accepted on 19 Feb 2018 and first published on 19 Feb 2018


Article type: Research Article
DOI: 10.1039/C7QO01140G
Citation: Org. Chem. Front., 2018,5, 1262-1266
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    Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis

    F. Xia, D. Zhang, C. Wu, H. Geng, W. Xu, Y. Zhang, X. Yang, H. Qin and G. Xu, Org. Chem. Front., 2018, 5, 1262
    DOI: 10.1039/C7QO01140G

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