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Issue 7, 2018
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Highly meta-selective halogenation of 2-phenylpyridine with a ruthenium(I) catalyst

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Abstract

We report a concise, versatile, and practical method for PhI(OCOCF3)2 mediated direct meta-C–H monohalogenation of 2-phenylpyridine and its derivatives via an Ru(I)-catalyzed reaction. The significant advantage of this transformation is the creation of a highly site-selective C–X bond by using NXS as halogenating agents under mild reaction conditions.

Graphical abstract: Highly meta-selective halogenation of 2-phenylpyridine with a ruthenium(i) catalyst

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Publication details

The article was received on 19 Dec 2017, accepted on 19 Jan 2018 and first published on 26 Jan 2018


Article type: Research Article
DOI: 10.1039/C7QO01133D
Citation: Org. Chem. Front., 2018,5, 1118-1123
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    Highly meta-selective halogenation of 2-phenylpyridine with a ruthenium(I) catalyst

    G. M. Reddy, N. S. Rao and H. Maheswaran, Org. Chem. Front., 2018, 5, 1118
    DOI: 10.1039/C7QO01133D

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