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Co(III)-Catalyzed N-chloroamide-directed C–H activation for 3,4-dihydroisoquinolone synthesis

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Abstract

The synthesis of 3,4-dihydroisoquinolone via Co(III)-catalyzed C–H activation has been achieved for the first time. N-Chloroamides as a C–H activation directing synthon react effectively with alkenes at room temperature, enabling the incorporation of diverse reactive functionalities and substitution patterns into the target heterocycles.

Graphical abstract: Co(iii)-Catalyzed N-chloroamide-directed C–H activation for 3,4-dihydroisoquinolone synthesis

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Publication details

The article was received on 16 Dec 2017, accepted on 04 Jan 2018 and first published on 05 Jan 2018


Article type: Research Article
DOI: 10.1039/C7QO01124E
Citation: Org. Chem. Front., 2018, Advance Article
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    Co(III)-Catalyzed N-chloroamide-directed C–H activation for 3,4-dihydroisoquinolone synthesis

    X. Yu, K. Chen, Q. Wang, W. Zhang and J. Zhu, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO01124E

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