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Synthesis of chiral sultams with two adjacent stereocenters via palladium-catalyzed dynamic kinetic resolution

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Abstract

A palladium-catalyzed intramolecular asymmetric reductive amination of racemic α-branched ketones bearing the poorly nucleophilic sulfonamides has been successfully developed through dynamic kinetic resolution, providing chiral δ-sultams with two contiguous stereogenic centers with high diastereoselectivity and enantioselectivity.

Graphical abstract: Synthesis of chiral sultams with two adjacent stereocenters via palladium-catalyzed dynamic kinetic resolution

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Publication details

The article was received on 06 Dec 2017, accepted on 16 Jan 2018 and first published on 16 Jan 2018


Article type: Research Article
DOI: 10.1039/C7QO01098B
Citation: Org. Chem. Front., 2018, Advance Article
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    Synthesis of chiral sultams with two adjacent stereocenters via palladium-catalyzed dynamic kinetic resolution

    B. Song, M. Chen and Y. Zhou, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO01098B

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