Jump to main content
Jump to site search


Palladium-catalyzed CO-free cyclizative carbonylation of 2-benzylpyridines leading to pyridoisoquinolinones

Author affiliations

Abstract

A CO-free palladium-catalyzed cyclizative carbonylation of 2-benzylpyridines was developed, leading to pyridoisoquinolinones. This procedure proceeded with the sequential carbonylation of the ortho-C–H bond and the dearomative C–N bond formation. The combination of acetic anhydride and formic acid rather than toxic CO gas was employed in this reaction. The ortho-C–H palladation intermediate palladacycle, which showed comparable activity during this reaction, was well characterized. Notably, N-phenyl-2-pyridinamine also worked well to provide 11H-pyrido[2,1-b]quinazolin-11-one.

Graphical abstract: Palladium-catalyzed CO-free cyclizative carbonylation of 2-benzylpyridines leading to pyridoisoquinolinones

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Dec 2017, accepted on 15 Dec 2017 and first published on 19 Dec 2017


Article type: Research Article
DOI: 10.1039/C7QO01081H
Citation: Org. Chem. Front., 2018, Advance Article
  •   Request permissions

    Palladium-catalyzed CO-free cyclizative carbonylation of 2-benzylpyridines leading to pyridoisoquinolinones

    R. Yang, J. Yu, S. Sun and J. Cheng, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO01081H

Search articles by author

Spotlight

Advertisements