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Recent advances in the intramolecular Mannich reaction in natural products total synthesis

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Abstract

The Mannich reaction has been widely used to effectively construct C–N and C–C bonds in organic synthesis. This review focuses on selected applications of the intramolecular Mannich reaction as a key step in the total synthesis of natural products (2000–2017). The organization of the synthetic applications is based on the structure of newly-formed skeletons using the intramolecular Mannich reaction, which include aza-fused rings and aza-bridged rings.

Graphical abstract: Recent advances in the intramolecular Mannich reaction in natural products total synthesis

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Publication details

The article was received on 01 Dec 2017, accepted on 04 Jan 2018 and first published on 09 Jan 2018


Article type: Review Article
DOI: 10.1039/C7QO01079F
Citation: Org. Chem. Front., 2018, Advance Article
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    Recent advances in the intramolecular Mannich reaction in natural products total synthesis

    Y. Shi, Q. Wang and S. Gao, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO01079F

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