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Recent advances of Intramolecular Mannich Reaction in Natural Products Total Synthesis

Abstract

The Mannich reaction has been wildly used to effectively construct C-N and C-C bonds in organic synthesis. This review will focus on selected applications of intramolecular Mannich reaction as key step in the total synthesis of natural products (2000-2017). The organization of the synthetic applications is based on the structure of newly formed skeleton using intramolecular Mannich reaction, which includes aza-fused rings, and aza-bridged rings.

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Publication details

The article was received on 01 Dec 2017, accepted on 04 Jan 2018 and first published on 09 Jan 2018


Article type: Review Article
DOI: 10.1039/C7QO01079F
Citation: Org. Chem. Front., 2018, Accepted Manuscript
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    Recent advances of Intramolecular Mannich Reaction in Natural Products Total Synthesis

    Y. Shi, Q. Wang and S. Gao, Org. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C7QO01079F

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