Jump to main content
Jump to site search


An uncommon multicomponent reaction involving nucleophilic heterocyclic carbenes: facile synthesis of fully substituted cyclopentanones

Author affiliations

Abstract

An unprecedented three component reaction involving arylidene oxazolone, enal and NHC, leading to the synthesis of fully substituted cyclopentanone derivatives with three contiguous stereocenters, is reported. This reaction illustrates the rare example of a multicomponent process involving NHCs, where the NHC-bound enolate is isolated by the interception of the NHC-homoenolate with arylidene oxazolone.

Graphical abstract: An uncommon multicomponent reaction involving nucleophilic heterocyclic carbenes: facile synthesis of fully substituted cyclopentanones

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Nov 2017, accepted on 10 Jan 2018 and first published on 11 Jan 2018


Article type: Research Article
DOI: 10.1039/C7QO01051F
Citation: Org. Chem. Front., 2018, Advance Article
  •   Request permissions

    An uncommon multicomponent reaction involving nucleophilic heterocyclic carbenes: facile synthesis of fully substituted cyclopentanones

    J. Krishnan, A. Jose, B. S. Sasidhar, E. Suresh, R. S. Menon and V. Nair, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO01051F

Search articles by author

Spotlight

Advertisements