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An Uncommon Multicomponent Reaction Involving Nucleophilic Heterocyclic carbenes: Facile Synthesis of Fully Substituted Cyclopentanones

Abstract

An unprecedented three component reaction involving arylidene oxazolone, enal and NHC, leading to the synthesis of fully substituted cyclopentanone derivatives with three contiguous stereocenters is reported. This reaction illustrates the rare example of a multicomponent process involving NHCs, where the NHC-bound enolate is isolated by the interception of the NHC-homoenolate with arylidene oxazolone.

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Publication details

The article was received on 23 Nov 2017, accepted on 10 Jan 2018 and first published on 11 Jan 2018


Article type: Research Article
DOI: 10.1039/C7QO01051F
Citation: Org. Chem. Front., 2018, Accepted Manuscript
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    An Uncommon Multicomponent Reaction Involving Nucleophilic Heterocyclic carbenes: Facile Synthesis of Fully Substituted Cyclopentanones

    V. Nair, J. Krishnan, A. Jose, S. B. S, E. Suresh and R. S. Menon, Org. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C7QO01051F

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