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Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction

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Abstract

The Hofmann carbylamine reaction is a very attractive route for preparing isocyanides directly from primary amines. However, its environmentally friendly potential is reduced by the use of hazardous chloroform in large excess. Herein, we report an innovative and very efficient mechanically activated synthesis of isocyanides based on the reaction of amines with chloroform in the presence of solid NaOH and without extra-solvent addition.

Graphical abstract: Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction

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Publication details

The article was received on 07 Nov 2017, accepted on 08 Dec 2017 and first published on 11 Dec 2017


Article type: Research Article
DOI: 10.1039/C7QO01006K
Citation: Org. Chem. Front., 2018, Advance Article
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    Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction

    R. Mocci, S. Murgia, L. De Luca, E. Colacino, F. Delogu and A. Porcheddu, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO01006K

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