Jump to main content
Jump to site search

Issue 6, 2018
Previous Article Next Article

Copper-catalyzed α-C–H amidation of simple ethers through C(sp3)–H/N–H cross dehydrogenative coupling

Author affiliations

Abstract

An efficient copper-catalyzed α-C–H amidation of simple ethers with N-(8-quinolyl)amides through C(sp3)–H/N–H cross dehydrogenative coupling was developed. Chelation assistance was employed for the formation of an active copper amide species which can couple with the α-carbon-centered radical generated from simple ethers. This method was applicable to both alkyl and aryl amides as well as various cyclic and acyclic ethers. It also possessed the merit of air and moisture tolerance.

Graphical abstract: Copper-catalyzed α-C–H amidation of simple ethers through C(sp3)–H/N–H cross dehydrogenative coupling

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Nov 2017, accepted on 21 Dec 2017 and first published on 22 Dec 2017


Article type: Research Article
DOI: 10.1039/C7QO01003F
Citation: Org. Chem. Front., 2018,5, 967-971
  •   Request permissions

    Copper-catalyzed α-C–H amidation of simple ethers through C(sp3)–H/N–H cross dehydrogenative coupling

    Q. Yue, Z. Xiao, Z. Ran, S. Yuan, Q. Zhang and D. Li, Org. Chem. Front., 2018, 5, 967
    DOI: 10.1039/C7QO01003F

Search articles by author

Spotlight

Advertisements