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Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

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Abstract

A nickel-catalyzed direct difluoromethylation of aryl boronic acids has been developed for the first time, demonstrating good efficiency, mild conditions, and good functional-group compatibility. The key to success is the combination of different kinds of readily available nitrogen and phosphine ligands with a nickel source, which can generate a variety of easily tunable catalysts in situ to promote the difluoromethylation of a broad scope of aryl boronic acids.

Graphical abstract: Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

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Publication details

The article was received on 13 Oct 2017, accepted on 31 Oct 2017 and first published on 01 Nov 2017


Article type: Research Article
DOI: 10.1039/C7QO00934H
Citation: Org. Chem. Front., 2018, Advance Article
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    Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

    J. Sheng, H. Ni, K. Bian, Y. Li, Y. Wang and X. Wang, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00934H

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